I'm taking hydrocortisone. Is it incompatible with nutritional supplements?

Hello Javier,

In general terms, hydrocortisone is not incompatible with most nutritional supplements, but it depends greatly on the type of supplement you are taking and on the dose of hydrocortisone.

If hydrocortisone is used for a short period — as in some treatments for allergies or inflammatory conditions — there are usually no problems with common vitamins or minerals.

However, when hydrocortisone treatment is prolonged or given at high doses, some aspects deserve attention. Corticosteroids can promote the loss of calcium and vitamin D, increase the risk of osteoporosis, raise blood glucose and alter potassium levels. In these cases, the doctor may recommend calcium and vitamin D supplements, always on an individual basis.

It is also important to be cautious with some products of natural origin. For example, St John's wort (Hypericum) can reduce the effect of hydrocortisone, while liquorice can enhance some of its side effects, such as fluid retention or increased blood pressure.

As for supplements such as magnesium, omega-3 fatty acids, vitamin B12, zinc or probiotics, they can generally be used without problems, although it is always advisable to tell your doctor about all the products you are taking.

My advice is not to assume that a supplement is completely harmless just because it is “natural”. Some can interact with medications or alter their effectiveness.

If you can tell me which nutritional supplement you wish to take, I will be able to advise you much more specifically.

I hope I have answered your question. Warm regards.