Ask the Doctor

Ask the Doctor

Real patient questions, answered personally by our medical team. Each case is reviewed individually and in full confidentiality.

Featured answers

Skin health

How can I tell the difference between a normal mole and a melanoma? What should I look out for?

Hello, Melanoma is a less common type of skin cancer than the ones mentioned above, but it is more significant because it can spread if not detected in time. The good news is that, when diagnosed early, the outlook is usually very good. It can appear on an existing mole that changes, or as a new spot. The ABCDE rule This is a simple way to remember the warning signs of a mole: A — Asymmetry: one half does not match the other. B — Border: irregular, blurred or jagged edges. C — Colour: multiple colours or shades (brown, black, red, white or bluish) within the same lesion. D — Diameter: larger than about 6 mm (roughly the size of a pencil eraser), although smaller ones can also be of concern. E — Evolution: any change in size, shape, colour, texture or symptoms (itching, bleeding). The 'ugly duckling' sign In addition to the ABCDE rule, pay attention to any mole that stands out from the rest: if you have many similar moles and one looks different from all the others, it deserves to be assessed. Signs that should prompt you to seek advice a mole that changes in size, shape or colour; a mole that itches, bleeds or becomes rough; a new spot that appears and grows on an adult's skin; a mole that looks different from all the others. What should you do? If you notice any of these signs, please request an in-person medical assessment. There is no need to be alarmed, but it is important not to delay: having a mole checked in good time is always the best decision. Check your skin regularly, protect yourself from the sun, and do not hesitate to seek advice about any lesion that concerns you. Warm regards, Doctor Florian A. Vallecillo Cabrera

General

Today there is a solar eclipse. Can I look at it with regular sunglasses if I only do so for a few seconds? What can happen if I look directly at the Sun?

Hello, Elena, The answer is very clear: you should not look directly at the Sun during an eclipse using only regular sunglasses, even if they are very dark, polarised, or of good quality. Nor do I recommend thinking that 'it will only be for a few seconds'. Looking directly at the Sun can cause an injury known as solar retinopathy or photic retinopathy, which particularly affects the macula — the central area of the retina responsible for our sharpest vision. The problem is that the retina has no pain receptors. This means you can be causing an eye injury without feeling any pain or immediately noticing that you are damaging your eyes. Symptoms may appear afterwards, even hours later. These may include: blurred vision; the appearance of a dark spot or blind spot in the centre of your vision; distortion of images; difficulty reading or making out fine details; altered colour perception; reduced visual acuity. In some patients, vision improves gradually over the following months, but the damage can be permanent and may leave a lasting loss of central vision. Why are regular sunglasses not suitable? Because they are designed to reduce ambient brightness and protect us from ultraviolet radiation during everyday exposure, but they are not designed for looking directly at the Sun. Even extremely dark sunglasses are insufficient. To observe the partial phases of an eclipse directly, we need specially designed solar viewing glasses that comply with the international standard ISO 12312-2. These glasses are thousands of times darker than conventional sunglasses. Before using them, we should check that they are not scratched, punctured, worn, or damaged. Can I wear two pairs of sunglasses on top of each other? No. Two, three or four pairs of sunglasses still do not become certified glasses for solar observation. I also advise against using X-rays, smoked glass, photographic negatives, CDs, homemade filters or any other improvised method. What about looking through a mobile phone? We must be careful with that as well. I do not recommend using the phone screen as an excuse to point directly at the Sun while we end up accidentally looking straight at it. And we should never look directly at the Sun through binoculars, telescopes, cameras or other optical instruments without solar filters that have been specifically designed and correctly fitted to the front of the device. This is even more dangerous because the lenses concentrate solar radiation and can cause serious eye injuries in a very short time. Is there any moment during a total eclipse when it can be viewed without glasses? There is one very specific exception. During a truly total eclipse, only during the brief instants in which the Moon completely covers the bright surface of the Sun may you look directly at it. But this is only valid if you are truly within the path of totality. As soon as the smallest bright fragment of the Sun reappears, we must immediately put our eclipse glasses back on. If you are not completely certain that you are in the totality phase, my recommendation is simple: keep your solar protection glasses on. Special care with children We must be even stricter when it comes to children. They should not observe the eclipse without adult supervision, and we must personally check that the glasses are correctly in place before they look toward the Sun. A child may remove their glasses out of curiosity at precisely the most dangerous moment. What should I do if I have looked at the eclipse without protection? If after looking directly at the Sun you notice blurred vision, a central blind spot, distorted images, colour changes or any loss of vision, you should seek an ophthalmological assessment as soon as possible. Do not wait for pain to appear because, as I have explained, retinal damage can occur without pain. My message for today is very simple: Enjoy the eclipse. It is an extraordinary phenomenon, but our eyes are with us for life. Only use glasses that are specifically designed and certified for solar observation. Conventional sunglasses are not suitable, regardless of their price, darkness or quality. And for a few seconds of curiosity, it is not worth risking retinal damage that, in some cases, may stay with us forever. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Elena
Laser

Can I keep using minoxidil for my beard after a CO₂ laser session for acne scars?

Hello, Javier: After a fractional CO₂ laser session, it is advisable not to apply minoxidil to the treated area until the skin has restored its barrier function. The CO₂ laser produces a controlled renewal of the skin through microcolumns of treatment. During the first few days, the skin remains inflamed, more sensitive and with a reduced ability to protect itself from potentially irritating substances. Most minoxidil formulations in foam or solution contain alcohol or other excipients that can cause stinging, intense irritation, delay healing or promote greater absorption of the medication while the skin has not yet recovered. In general terms, I advise waiting between 3 and 5 days before resuming minoxidil. However, if the treatment was more intense or recovery is slower, it may be preferable to wait until the crusts, intense redness and sensation of irritation have disappeared. In some patients this may require 5 to 7 days, or even more, depending on the intensity of the procedure. During that period, the most important thing is to follow the post-laser care correctly: • Keep the skin well hydrated with the cream recommended by the specialist. • Avoid irritating products, such as exfoliating acids, retinoids or products containing alcohol. • Use a broad-spectrum sunscreen and avoid direct sun exposure. • Do not pick at the crusts or the areas that are healing. If you use minoxidil on another area that has not been treated with the laser, such as the scalp, you can continue applying it as usual, making sure it does not come into contact with the treated skin. If in doubt, always follow the instructions of the doctor who performs the treatment, since recovery time can vary according to the power of the laser, the depth of the treatment and each patient's characteristics. I hope I have resolved your question and I wish you an excellent recovery. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Javier
Second opinion

I was prescribed enalapril 5 mg without being hypertensive, only to control the blood pressure spikes that appear during my fibromyalgia flare-ups. Instead of enalapril 5 mg, could I take amlodipine 5 mg?

Hello, María. In principle, it is not advisable to replace enalapril with amlodipine on your own initiative, even though both medications are used to treat high blood pressure. Enalapril and amlodipine belong to different families and act through different mechanisms. The choice of one or the other depends on factors such as age, associated conditions, kidney function, other treatments and the reason why blood pressure rises. If your blood pressure spikes appear only during fibromyalgia pain flare-ups, it is important to assess whether these rises are a transient response to pain and stress. In many cases, the best treatment is to control the fibromyalgia flare-up properly, since as the pain decreases, blood pressure usually normalises. If enalapril was prescribed specifically for those occasional spikes, I advise you not to switch it for amlodipine without first consulting the doctor who knows your medical history. If you have had side effects with enalapril, such as a persistent cough, dizziness or any other discomfort, there are alternatives that may be more suitable, but the decision must be individualised. In addition, it would be advisable to have several blood pressure measurements, both during flare-ups and in pain-free periods, to confirm whether hypertension really exists or whether these are only transient rises related to pain. Key points: • Do not replace one antihypertensive with another without medical indication. • Intense pain can cause transient rises in blood pressure. • If elevated readings persist outside the flare-ups, a work-up to rule out hypertension is advisable. • Seek urgent care if you have very high blood pressure accompanied by chest pain, difficulty breathing, visual disturbances, weakness or neurological symptoms. I hope this has been helpful. Kind regards, Doctor Florian A. Vallecillo Cabrera

— María
Laser

I had a laser treatment three days ago and my skin is still red and somewhat warm. Is this normal, or should I be concerned?

Hello, Laura, First of all: please don't worry. It is quite normal for the skin to still look a little red and feel warm three days after a laser treatment. When laser is applied, the skin receives a stimulus and responds with a small, controlled inflammation. That redness and warmth are, in many cases, simply a sign that your skin is reacting and getting to work. It is normal for these sensations to gradually subside over the following days. What do I recommend in the meantime? Treat your skin gently during these days: keep it well moisturised, apply a good sunscreen every morning, and avoid direct sun exposure, which is your main concern right now. Also avoid extra heat sources (saunas, very hot water), and do not rub or scratch the area even if it feels a little itchy. And when would I be concerned? There are some signs to watch out for. If the redness gets worse instead of better, or if you notice blisters, intense pain, discharge, unusual scabbing, or fever, please do not wait: in that case, it is best to see your doctor to rule out any complications. And one last thing, which matters to me: every skin type and every laser treatment is different. If you notice something that does not feel right, or if you would simply feel more at ease by checking in with us, I would rather you ask than sit at home with a lingering doubt. That is exactly what we are here for.

— Laura, 34
Skin health

Can the very sudden and widespread appearance of seborrhoeic keratoses over a few weeks, with new lesions continuing to emerge, be compatible with the Leser-Trélat sign? What studies or tests would be advisable to distinguish a benign presentation from a possible paraneoplastic syndrome?

Hello, Yes. A truly sudden and widespread appearance of seborrhoeic keratoses — especially when new lesions continue to emerge over the course of a few weeks or months — may bring to mind what is known as the Leser-Trélat sign. However, it is important not to be alarmed: this is an uncommon and, moreover, a debated sign. Seborrhoeic keratoses are extremely common benign lesions and can increase considerably with age without any malignant disease being present. What raises suspicion? What raises suspicion is a very striking change compared to the usual situation: the appearance of numerous lesions over a short period of time, rapid growth, intense itching and, in particular, the association with symptoms such as unexplained weight loss, reduced appetite, marked fatigue, anaemia, digestive bleeding or persistent changes in bowel habit. What investigations are advisable? There is no specific test that can confirm or rule out the Leser-Trélat sign. The first step would be to carry out a thorough medical examination of the skin and a dermatoscopy to confirm that the lesions are indeed seborrhoeic keratoses. If any of them show atypical features, a biopsy may be indicated. If the appearance has been truly explosive and there is no obvious explanation, it may be reasonable to complete the work-up with a full blood count, liver and kidney function tests, blood glucose, ferritin and inflammatory markers (CRP/ESR), along with a full clinical history and general physical examination. Further investigations should subsequently be tailored to the individual based on age, sex, family history, risk factors and symptoms, while also ensuring that the usual cancer screening programmes are up to date. I do not consider it appropriate to routinely perform a whole-body CT scan or multiple tumour markers in an asymptomatic person solely because they present with seborrhoeic keratoses. The true Leser-Trélat sign has been described primarily in association with gastrointestinal adenocarcinomas, particularly gastric ones, although it has also been reported in connection with other tumours. Therefore, an exceptionally rapid and widespread appearance does warrant a medical assessment and investigation, but it does not automatically mean that cancer is present. Kind regards, Dr Florian André Vallecillo Cabrera

Skin health

A jellyfish stung me on the forearm three weeks ago. The lesion has improved, but I still have quite a significant mark. Is it normal for it to take so long to disappear? What should I do to help my skin recover?

Hello Carolina, The first thing I want to convey is reassurance. Three weeks after a jellyfish sting, a visible mark can still remain on the skin, especially if the initial reaction was intense. A jellyfish sting is not simply a superficial irritation. Its tentacles contain microscopic structures called nematocysts that release toxic substances into the skin. This can cause pain, inflammation, redness and linear lesions that even reproduce the shape of the tentacle contact. In most cases the acute phase improves within a few days, but the inflammation left in the skin can take much longer to disappear. How long can the mark last? It is very variable. After a significant reaction, the skin may keep a reddish, brown or purplish colour for several weeks. In some people post-inflammatory hyperpigmentation appears afterwards — that is, the inflammation goes away but a residual mark remains. This pigmentation may need several weeks or even a few months to fade progressively. Therefore, if after three weeks the lesion is clearly improving, is not growing, does not hurt and shows no signs of infection, the fact that a mark still exists does not necessarily mean that something abnormal is happening. Here, patience is also part of the treatment. What should you do immediately after a jellyfish sting? If it happens again, the first thing is to calmly leave the water. If any tentacle remnants are stuck to the skin, they should be removed carefully, preferably with tweezers or without touching them directly with your hands. The area can initially be rinsed with sea water, avoiding rubbing the skin vigorously. I do not recommend scratching, rubbing with a towel or using improvised home remedies. First-aid treatment can vary depending on the jellyfish species and the geographical region, so products such as vinegar should not be considered a universal recommendation for all stings. When there is significant pain, the controlled application of heat can help with certain stings. And, of course, if immediately after the sting there is difficulty breathing, intense dizziness, vomiting, loss of consciousness, generalised swelling or a major allergic reaction, it is a medical emergency. What do I do now, three weeks later? At this point we are no longer treating the venom, but the inflammatory consequences it has left on the skin. If there is still inflammation, itching or significant redness, it may be necessary to consider a topical anti-inflammatory treatment for a few days. I do not recommend starting corticosteroids or other medicines on your own without first examining the lesion. If what mainly remains is a mark, my priority would be simple: protect the skin and give it time to recover. Use a broad-spectrum SPF 50+ sunscreen daily on the area and avoid exposing the lesion directly to the sun. This is especially important because ultraviolet radiation can make post-inflammatory hyperpigmentation darken and take much longer to fade. You can also use a simple repairing moisturiser, without fragrances or potentially irritating substances. During this phase I would avoid exfoliants, acids, retinoids and other aggressive treatments on the area until the skin has fully recovered. Will it leave a permanent scar? Not necessarily. Often what the patient interprets as a scar is actually residual pigmentation caused by the inflammation, and it can fade progressively. However, the most intense reactions may, exceptionally, leave persistent pigmentation changes or a true scar. There are also delayed inflammatory reactions to jellyfish stings that can reappear weeks later. That is why, if after several weeks the lesion remains very inflamed, itches intensely again, becomes thicker, blisters appear or you see no progressive improvement, I recommend having a medical assessment of the skin. You should also seek advice sooner if local warmth, increasing pain, discharge, pus, fever or redness spreading around the lesion appear, because a secondary infection may have developed. In your case, if three weeks have passed and you tell me the lesion is improving, I would be patient. Protect the area very well from the sun, moisturise it and avoid manipulating it. The skin has its own repair times and, after a significant inflammatory reaction, it does not always regain its normal appearance in just a few days. Warm regards,

— Carolina
Skin health

I have vitiligo over more than 70% of my body. As I have relatively little skin left with my natural colour, could I depigment the rest to achieve an even tone?

Hello Patricia, I fully understand the logic of your question after living with such extensive vitiligo for years. However, I want to be very clear with you: deliberately depigmenting the healthy skin that still keeps its colour is not a trivial cosmetic decision and should never be done on your own. Therapeutic depigmentation does indeed exist for certain patients with very extensive vitiligo. So I cannot tell you it is a procedure that is never performed. But it is reserved for highly selected situations, usually when the vitiligo is extensive, stable, affects a large part of the body surface and the reasonable chances of repigmentation are very limited. What does it involve? Gradually removing the melanin from the areas that still hold pigment, in order to try to achieve a more uniform appearance. The problem is that we are talking about deliberately destroying normal, functional pigmentation. And this has consequences. Melanin is not there only to determine the colour of our skin. It is part of our natural system of protection against ultraviolet radiation. A person with very extensive depigmentation will have to be especially rigorous with sun protection for the rest of their life. In addition, therapeutic depigmentation may be permanent or hard to reverse. Nor is the result necessarily perfectly uniform: resistant areas, irregular repigmentation, irritation, dermatitis and differences in tone can appear. For this reason, it should not be approached as if it were simply «removing the colour that is left». I also consider it essential to weigh the psychological impact of a decision of this magnitude. Not because wanting uniform skin implies having a mental health problem, but because we are talking about potentially irreversibly modifying an important bodily characteristic. Before doing so, we must be sure that the person fully understands what they are gaining, what they are losing and how they may feel afterwards. That is why, faced with a patient whose vitiligo affects roughly 70% of the body surface, I would not directly recommend depigmentation simply because there is less pigmented skin left. First I would carry out a complete medical assessment of the skin: the extent and stability of the vitiligo, the location of the residual areas, previously performed treatments, the real chances of repigmentation and the impact of the disease on quality of life. We now also have different therapeutic strategies for vitiligo, and the approach must be individualised before assuming that the only possible solution is to remove the remaining pigment. And I especially want to insist on one thing: I do not recommend buying depigmenting creams over the Internet, compounded formulas of dubious origin, or using substances intended to bleach the skin without medical supervision. Trying to achieve extensive body depigmentation on your own can cause chemical burns, severe dermatitis, permanent pigmentation changes and other complications. Medicine also means knowing when we should stop before carrying out a treatment. In extremely extensive vitiligo, therapeutic depigmentation can indeed be considered, but it must be the result of a carefully weighed medical decision shared with the patient, not an improvised cosmetic solution. My recommendation in your case would be to first have a specific medical consultation about vitiligo, study all the available alternatives and only then decide which is the most appropriate and safest path for you. Warm regards,

— Patricia
Skin health

I have significant psoriasis and my skin specialist has suggested starting treatment with methotrexate and folic acid. I had always been treated with creams and did not know this treatment existed, including as an injection. What is methotrexate and how does it work?

Hello Isabel, That is an excellent question and, in fact, a very common concern when we propose this treatment for the first time. Psoriasis is not solely a skin disease. It is actually a chronic inflammatory disease of immune origin, in which the immune system sends signals that make skin cells multiply much faster than normal. As a result, red plaques, scaling, itching and, in some patients, pain or joint involvement appear. When psoriasis is mild, local treatments such as creams or ointments are usually enough. However, when the disease is more extensive, significantly affects quality of life or topical treatments are no longer sufficient, we need to act from within the body. This is where methotrexate comes in. Methotrexate is a medication we have been using for decades and whose action we understand very well. At the doses used in psoriasis, it works by regulating the immune system's response and reducing inflammation, which helps to curb the excess activity responsible for the lesions. In other words, it does not only treat the visible plaques, but acts on the mechanism that produces them. It can be given as tablets or as a subcutaneous injection once a week. In many patients I prefer the subcutaneous route because it offers more stable absorption and often causes fewer digestive complaints. It is important to remember that methotrexate is taken only once a week, never every day. This is one of the most important aspects of the treatment. Along with methotrexate we usually prescribe folic acid (Acfol®). This is not because you have a vitamin deficiency, but because it helps reduce some possible side effects of the treatment, such as digestive discomfort, mouth ulcers or certain laboratory abnormalities. It should be taken on the day indicated by your doctor, normally on a different day from the methotrexate. Like any systemic treatment, it requires regular monitoring. Before starting it and during treatment we carry out blood tests to check the function of the liver, the kidneys and the blood cells. Thanks to this monitoring, the treatment is usually very safe when it is well indicated and properly controlled. There are also nowadays the so-called biologic medicines, which are very effective for certain patients. However, methotrexate remains one of the reference treatments in moderate to severe psoriasis because of its efficacy, its extensive track record and its excellent benefit-to-risk ratio in many patients. My advice is not to be afraid of the name of the medication. The methotrexate used in skin medicine is given at doses far lower than those used in oncology and with a completely different aim: to control inflammation and improve quality of life. When the treatment is well indicated and the patient carries out the recommended check-ups, the results are usually very satisfactory and many people manage to keep their psoriasis under control for years. I hope I have answered your question. Warm regards, Doctor Florian A. Vallecillo Cabrera

— Isabel
Skin health

I have athlete's foot and the area seems more and more irritated. What treatment should I follow? Can I go to the pool, to the beach, play sport or keep running?

Hello Alejandro, Athlete's foot, whose medical name is tinea pedis, is a superficial skin infection caused by fungi. It usually appears between the toes, although it can also affect the sole and the sides of the foot. It can cause itching, scaling, cracks, bad odour, small blisters or whitish, softened skin between the toes. When the skin is very macerated, cracked or painful, a bacterial infection may be added, so we should not regard it merely as a cosmetic problem. The usual treatment is to apply a topical antifungal to clean, completely dry skin. Depending on the active ingredient, it may be used for one or several weeks. It is essential to respect the indicated frequency and duration, covering not only the visible area but also a small margin of surrounding skin. Even if the lesion starts to improve quickly, the treatment should not be stopped early. Stopping too soon can leave active fungi and encourage the infection to return. Topical corticosteroids used alone are also not suitable, as they can temporarily mask the symptoms while the infection continues to spread. When athlete's foot is very extensive, recurrent, also affects the nails or does not improve with a properly carried-out treatment, it may be necessary to confirm the diagnosis with a skin sample and to consider an oral antifungal. This treatment must be prescribed and monitored by a doctor. However, medication alone is usually not enough. To cure athlete's foot properly and prevent it from returning, it is essential to control moisture and follow a series of daily measures. Keeping the feet dry Wash the feet once a day with water and a mild product. Then dry them carefully, especially between the toes. It is not enough to dry only the sole of the foot. Use a personal towel and do not share it. After drying the infected area, wash your hands to avoid spreading the fungus to other parts of the body. Changing socks and footwear Change your socks at least once a day and whenever they are damp with sweat. If you exercise and sweat a lot, it may be necessary to change them immediately afterwards. Choose breathable socks or socks designed to wick away moisture. Avoid keeping wet socks on for hours. Alternate your footwear and let your shoes dry and air completely before wearing them again. During treatment, it can be useful to use an antifungal powder or spray specifically for the inside of the shoes, following the product instructions. Whenever possible, temporarily avoid very closed, tight or poorly breathable shoes. Can I run or play sport? It is not mandatory to stop exercising, but you must avoid the foot staying damp for a long time. The combination of sweat, heat, friction and closed footwear creates an environment favourable for the infection to persist. If you run or train, use clean, breathable socks, change them when you finish, take a shower and dry your feet very well. Do not stay afterwards in sweaty trainers and socks. If there are painful cracks, blisters, erosions or significant inflammation, it may be advisable to temporarily reduce activity until the skin begins to recover, as friction can worsen the lesions. Can I go to the swimming pool? While the infection is active, the most prudent thing is to temporarily avoid the pool, especially if the skin is open, macerated or very inflamed. The problem is not only the water. Changing rooms, showers and pool edges are damp surfaces where fungi can be transmitted easily. Walking barefoot can also favour a new exposure and contagion to other people. If you go, always use flip-flops, do not share towels or footwear and dry your feet completely when you leave. Do not stay in a wet swimsuit, socks or footwear. And swimming in the sea? Seawater does not cure athlete's foot. Although occasional bathing is generally not a major danger, keeping the foot damp or walking barefoot in showers, walkways and common areas can delay recovery or favour new contamination. If you bathe, dry your feet well immediately afterwards and avoid covering them for hours with closed footwear while they are still damp. Can I go to the sauna or the steam bath? I do not recommend it while the infection is active. Heat and humidity encourage maceration of the skin and create ideal conditions for the fungi to persist. Should I cover the lesion with a dressing? In general, it is not advisable to cover athlete's foot with an occlusive dressing. By preventing ventilation, moisture can accumulate, maceration can occur and the infection can worsen. If there is a crack that needs protection against friction, a suitable, breathable dressing should be used for the shortest possible time, following the recommendation of a healthcare professional. Preventing the fungus from spreading Do not scratch the lesions. The fungus can pass from the feet to the nails, the groin, the hands or other areas of the body. Do not share towels, socks, shoes, nail clippers or pedicure utensils. Regularly wash towels, socks and bathroom mats. Also check the nails. If they are yellowish, thickened, brittle or detached, there may be an associated nail infection acting as a reservoir and causing continual relapses. You should request a new medical evaluation if you do not see a clear improvement after correctly completing the treatment, if the infection recurs frequently or if it affects a very extensive area. Consult more quickly if increasing pain, warmth, inflammation, pus, intense bad odour, spreading redness, fever or difficulty walking appears. These signs may indicate a bacterial superinfection. I also recommend an early medical evaluation if you have diabetes, circulatory problems, reduced sensation in the feet or a disease that affects your defences. Athlete's foot usually heals well, but success depends as much on the antifungal as on keeping the feet dry, treating the footwear and avoiding the conditions that favour reinfection. I hope I have guided you. Warm regards.

— Alejandro
Skin health

I have been diagnosed with a fungal skin infection. Can I keep going to the swimming pool, the sea or the sauna? Is it better to cover the lesion with a dressing?

Hello Javier, This is a very common question and I'm glad you're asking it, because appropriate care is just as important as the treatment itself. In general, if you have a fungal skin infection (cutaneous mycosis), I do not recommend going to saunas or steam baths while the lesion is active. Heat and humidity create an environment that encourages fungal growth and can delay healing. As for the swimming pool or the sea, they are not absolutely forbidden, but it is preferable to avoid them until the infection is clearly under control, especially if the lesion is extensive or located in areas where it spreads easily, such as the feet. There is also the risk of passing it on to other people through shared damp surfaces, such as showers or changing rooms. If, for some reason, you cannot avoid bathing, it is important to dry the area very thoroughly immediately afterwards, apply the antifungal treatment as directed, and always use a clean towel for your personal use only. Another very frequent question is whether it is advisable to cover the lesion with a dressing or a bandage. In most cases, the answer is no. Fungi thrive better in warm, humid environments, and an occlusive dressing can encourage maceration of the skin, hinder healing and even facilitate a bacterial superinfection. The ideal approach is to keep the lesion clean, dry and exposed to the air whenever possible, to wear breathable cotton clothing and to avoid tight garments if the infection affects areas of friction. It is also worth remembering that the treatment must be maintained for the length of time indicated by the doctor, even if the lesion appears to have disappeared, since stopping it too soon is one of the most frequent causes of relapse. Finally, if you notice that the lesion is rapidly increasing in size, or that pus, intense pain, fever or significant redness appears around the affected area, it is advisable to come back for a consultation, as a bacterial infection requiring a different treatment may have developed. With good hygiene measures and by following the treatment correctly, most fungal infections heal without leaving any after-effects. I hope I have resolved your question. Warm regards.

— Javier
Aesthetic medicine

Lately I hear a lot about injectable peptides in aesthetic medicine. What exactly are they, how do they work and are they really worth it?

Hello Cristina, That's an excellent question. Peptides are one of the treatments currently generating the most interest in aesthetic and regenerative medicine, although they still raise many questions. Peptides are short chains of amino acids — that is, fragments of proteins that act as true “biological messengers”. Their role is to send signals to cells to stimulate certain natural processes in the body, such as collagen production, tissue repair, skin regeneration or the reduction of inflammation. Unlike other treatments that simply fill or add volume, peptides aim to improve the functioning of the skin itself, helping it recover part of its own regenerative capacity. In aesthetic medicine we use different types of peptides, since they do not all have the same function. Some are geared towards improving skin quality, others stimulate collagen formation, some help improve hydration and elasticity, and others are part of regenerative medicine treatments with applications that go beyond facial rejuvenation. Patients usually notice more luminous, firmer skin with better texture and better overall quality. It is important to understand that they do not produce an immediate change, as can happen with a hyaluronic acid filler. Their effect is progressive, because they work by stimulating the skin's natural repair mechanisms. I usually recommend an initial protocol of 3 to 4 sessions, spaced roughly two to four weeks apart, although the number may vary depending on age, the condition of the skin and each patient's goals. Afterwards, we usually carry out maintenance sessions every few months to preserve the results. In my clinical practice, I consider peptides a very interesting tool, especially in patients seeking natural rejuvenation without altering the features of the face. I frequently combine them with other treatments, such as polynucleotides, skinboosters, collagen biostimulators or laser technologies, as their effects are usually complementary. That said, it is also important to be prudent. In recent years many products marketed under the name “peptides” have appeared, but not all of them have the same level of scientific evidence or the same pharmaceutical quality. It is therefore essential to always place yourself in the hands of an experienced doctor who uses authorised, scientifically supported products. My philosophy in aesthetic medicine has always been the same: we are not trying to transform a face, but to help the skin age better, keeping a fresh, healthy and natural appearance. In that context, peptides are a very promising tool and, when properly indicated, can offer very satisfying results. I hope I have resolved your question. Warm regards.

— Cristina
General

I'm taking hydrocortisone. Is it incompatible with nutritional supplements?

Hello Javier, In general terms, hydrocortisone is not incompatible with most nutritional supplements, but it depends greatly on the type of supplement you are taking and on the dose of hydrocortisone. If hydrocortisone is used for a short period — as in some treatments for allergies or inflammatory conditions — there are usually no problems with common vitamins or minerals. However, when hydrocortisone treatment is prolonged or given at high doses, some aspects deserve attention. Corticosteroids can promote the loss of calcium and vitamin D, increase the risk of osteoporosis, raise blood glucose and alter potassium levels. In these cases, the doctor may recommend calcium and vitamin D supplements, always on an individual basis. It is also important to be cautious with some products of natural origin. For example, St John's wort (Hypericum) can reduce the effect of hydrocortisone, while liquorice can enhance some of its side effects, such as fluid retention or increased blood pressure. As for supplements such as magnesium, omega-3 fatty acids, vitamin B12, zinc or probiotics, they can generally be used without problems, although it is always advisable to tell your doctor about all the products you are taking. My advice is not to assume that a supplement is completely harmless just because it is “natural”. Some can interact with medications or alter their effectiveness. If you can tell me which nutritional supplement you wish to take, I will be able to advise you much more specifically. I hope I have answered your question. Warm regards.

— Javier
General

I've been taking iron for three months, but I still feel very tired. Is this normal?

Hello Laura, Yes, it can happen. Although many people start to feel better a few weeks after starting iron treatment, the tiredness does not always disappear immediately, and in some cases it can persist for several months. The first step is to check whether the treatment is actually working. This usually requires repeating a blood test and assessing how haemoglobin, ferritin (the body's iron stores) and other parameters related to iron metabolism have evolved. Sometimes the anaemia is corrected before the iron stores are replenished, which is why treatment is often maintained for several more months. It is also worth checking whether the iron is being absorbed correctly. Some foods or medicines — such as dairy products, calcium, certain antacids, or coffee and tea — can reduce its absorption if taken at the same time. Taking it with vitamin C or a glass of orange juice, on the other hand, can help. If after three months the tests have improved and the tiredness still continues, it is important to consider other possible causes. Fatigue is not always due to iron. Thyroid disorders, a vitamin B12 or vitamin D deficiency, sleep problems, stress, anxiety, depression, inflammatory diseases or even some infections can produce very similar symptoms. Therefore, if you continue to feel the same, my recommendation is to consult your doctor to review how the treatment is progressing and to assess whether further investigation with a new blood test or other tests is needed. The most important thing is not to assume that all the tiredness is due solely to a lack of iron. In most cases, once the cause is identified and treated appropriately, the symptoms improve gradually. I hope I have helped guide you. Warm regards.

— Laura
Aesthetic medicine

I'm 48, I smoked for years, I drink alcohol occasionally and I've had a lot of sun exposure throughout my life. I'm starting to notice more wrinkles and a loss of skin quality. I feel a bit lost with so many treatments: polynucleotides, exosomes, skinboosters, biostimulators… Which treatment would you recommend and how many sessions are usually needed?

Hello Elena, This is a question I hear very often in consultation. Today there are many aesthetic medicine treatments and it's normal to feel confused. However, rather than looking for “the best treatment”, what matters is choosing the treatment best suited to your skin. From what you describe, you have several factors that accelerate skin ageing: accumulated sun exposure, smoking and the passage of time itself. All of this promotes the loss of collagen, elastin and hydration, as well as the appearance of fine wrinkles, pigment spots and a more irregular texture. In these cases, my philosophy is not to start by filling wrinkles, but first to restore the health and quality of the skin. When the skin improves from within, the result is much more natural and long-lasting. I usually plan the treatment in several phases. The first is a regeneration phase, in which we can combine treatments such as polynucleotides, skinboosters or, in certain cases, collagen biostimulators. Each has a different role and, far from competing with one another, they usually complement each other. If there is also significant sun damage, pigment spots or a very altered texture, I often add a fractional laser procedure or rejuvenation technologies to stimulate a deeper renewal of the skin. In most patients, I usually recommend an initial cycle of 2 or 3 sessions, spaced three to four weeks apart, although the number may vary depending on the condition of the skin and each person's goals. Afterwards, once the desired improvement is achieved, it is advisable to have maintenance sessions every few months to preserve the results. I would like to make a clarification about exosomes, as they generate a lot of interest. Although the early results are promising, the scientific evidence is still evolving and I currently consider them a complementary treatment within an overall skin-regeneration strategy, not a substitute for procedures with stronger scientific support. My advice is not to choose a treatment because it is fashionable or because you have seen it on social media. What matters most is a complete medical assessment of your skin. Not everyone ages in the same way, and two 48-year-old patients may need completely different treatments. When the treatment plan is properly personalised, the goal is not to change the face, but to achieve skin that is more luminous, firmer, more even and healthy-looking, always respecting each person's expression and identity. I hope I have helped guide you. Warm regards.

— Elena, 48
salud femenina

I am 50 years old, I have a hormonal IUD and I am following hormone therapy for menopause. For the past week I have started having light bleeding and I am very worried. Could it be cancer?

Hello Julia, I fully understand your concern. It is very common for unexpected bleeding to cause fear, and for the first thing that comes to mind to be the possibility of cancer. However, I want to reassure you: the vast majority of bleeding in this situation is not caused by cancer. At 50, during perimenopause or the early years of menopause, the body goes through significant hormonal changes. In addition, using a hormonal IUD together with hormone replacement therapy can promote small bleeds or spotting, especially during the first months of treatment, after a dose change, or even after a long period without any bleeding. There are many benign causes that can explain this type of bleeding, such as the endometrium adapting to hormone therapy, small uterine polyps, slight thinning or thickening of the endometrium, or simply changes typical of this stage of life. This does not mean it should be ignored. Any bleeding after menopause or during hormone therapy deserves to be assessed, but assessing it does not mean there is a serious problem. In most cases, a gynaecological examination and a transvaginal ultrasound make it possible to identify the source of the bleeding and confirm that everything is within normal limits. Only in certain circumstances may the gynaecologist consider it necessary to perform an additional test, such as an endometrial biopsy. My advice is to book an appointment with your gynaecologist so they can assess you calmly. In the meantime, try not to anticipate the worst-case scenario. In my practice I often see this type of situation and, fortunately, most have a completely benign explanation. You should seek care sooner if the bleeding is heavy, lasts several days, is accompanied by intense pain, or if you feel dizzy or weak. I hope I have reassured and guided you. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Julia, 50
General

I'm 20 and I've had a lot of reflux for a year. I've tried several treatments, but it always comes back. Sometimes I just feel burning and other times reflux. I feel very sad because I can't get better. What can I do?

Hello, Laura: First of all, I want to tell you that I completely understand how you feel. Living with reflux for so long can greatly affect quality of life and cause anxiety or low mood. The good news is that, in most cases, it is possible to find the cause and improve the symptoms with the right approach. When reflux persists despite treatment, it is important to review several aspects: confirm that it really is gastro-oesophageal reflux disease, assess whether there is a hiatal hernia, a Helicobacter pylori infection, functional disorders of the oesophagus or even stress-related factors, which can heighten the perception of symptoms. It is also worth reviewing some habits that greatly influence reflux: avoid large meals at night, do not lie down until two or three hours after dinner, reduce alcohol, tobacco, coffee, carbonated drinks and very fatty or spicy foods, and maintain a healthy weight if overweight. If you have had recurring symptoms for a year, it would be advisable for a digestive-system specialist to assess the need for a gastroscopy or additional tests to reach an accurate diagnosis and tailor the treatment. Most importantly, do not lose hope. Many people with chronic reflux manage to control their symptoms once the cause is correctly identified and treatment is individualised. I hope this has helped, and I wish you a swift improvement. Kind regards.

— Laura, 20
Skin health

What does an actinic keratosis look like and how can I recognize it? Is it dangerous?

Hello, Actinic keratosis is a very common lesion caused by cumulative sun damage built up over the years. It appears most often on areas most exposed to the sun: the face, forehead, hairless scalp, ears, back of the hands and forearms. What does it look like? It is usually a small area that feels rough and uneven to the touch, often easier to notice with a finger than to see. It may have a dry scale or an adherent crust, and can be pinkish, reddish, yellowish or skin-coloured. There are frequently several lesions grouped together in the same area, and the surrounding skin shows other signs of sun damage, such as spots or wrinkles. Sometimes it itches slightly, flakes or bleeds when rubbed. Why does it matter? Actinic keratosis is considered a pre-cancerous lesion. Most do not progress, but a small proportion may transform over time into squamous cell carcinoma. That is why it is important not to ignore it. Signs that should prompt you to seek medical advice a lesion that grows, thickens or becomes hard; a lesion that ulcerates, bleeds or fails to heal; a lesion that becomes painful or tender; any rapid change in appearance. What should you do? The most appropriate step is an in-person medical assessment. Many actinic keratoses are treated simply and effectively when diagnosed early, and a routine check-up also allows the rest of the skin to be monitored. Above all, prevention: daily sun protection, avoiding peak sun radiation hours and regularly examining the areas most exposed to the sun. Warm regards, Doctor Florian A. Vallecillo Cabrera

Skin health

What does a basal cell carcinoma look like? How can it be told apart from a pimple or a wound that won't heal?

Hello, Basal cell carcinoma is the most common form of skin cancer. It grows slowly and locally, and very rarely spreads to other parts of the body; however, if left untreated, it can damage the surrounding tissues. It is associated primarily with cumulative sun exposure. What does it look like? The most typical presentation is a small, pearly or translucent raised area, sometimes with tiny visible blood vessels on the surface. It may also appear as a wound or sore that will not heal properly: it bleeds easily, forms a scab, partially heals, and then reopens. In other cases it presents as a pink patch, an area that resembles a scar without any prior injury, or a lesion with a raised border and a sunken centre. It appears most commonly on the face, nose, ears, neck, and other areas regularly exposed to the sun. How can it be distinguished from a spot or an ordinary wound? The key factor is time. An ordinary spot or wound will improve within a few weeks. Any lesion that does not heal over several weeks, that bleeds repeatedly, or that is slowly growing should be assessed by a specialist. Signs that should prompt you to seek advice a wound that has not healed in more than three or four weeks; a pearly or shiny lesion that is gradually growing; repeated bleeding from minimal contact; an area resembling a scar that appears for no apparent reason. What should you do? For any lesion with these characteristics, the sensible course of action is an in-person medical assessment. Basal cell carcinoma, when diagnosed early, responds very well to treatment. Please do not attempt to treat it yourself or wait to see whether it disappears. Warm regards, Doctor Florian A. Vallecillo Cabrera

General

Can I take honey or propolis if I am allergic to pollen?

Hello, Laura: Being allergic to pollen does not necessarily mean you cannot consume honey, but some caution is advisable. Honey can contain small amounts of pollen and other components from plants. Most people with seasonal pollen allergy tolerate it without problems, since the pollens that cause allergic rhinitis are mainly airborne, such as those from grasses, trees or weeds. However, allergic reactions to honey have been described, although they are rare. These reactions may appear as: • Itching or tingling in the mouth or throat. • Swelling of the lips, tongue or face. • Hives. • Difficulty breathing. • In exceptional cases, a severe allergic reaction. Regarding propolis, it is advisable to be even more cautious. It is a substance made by bees from plant resins and can cause allergic reactions, especially contact dermatitis, mouth irritation or reactions after ingestion. The risk may be higher in people sensitive to bee products, to balsam of Peru or to certain plant resins. If you have consumed honey before and never had symptoms, you can probably continue taking it normally. However, if you have never tried it, have a history of significant allergic reactions, poorly controlled asthma or an allergy to bee-derived products, it would be preferable to consult an allergist before consuming honey or propolis. I do not recommend doing a "test" at home by taking a small amount if an allergy is suspected. When tolerance needs to be confirmed, the assessment must be individualised and, in some cases, done through a test supervised by a specialist. In summary: pollen allergy does not automatically require avoiding honey, but propolis has a higher allergenic potential and should be used with more caution. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Laura
Hair

I have been using topical finasteride spray for hair loss and I read that it can cause breast cancer. This has frightened me and I have stopped the treatment. Is that risk actually real?

Hello, Ana, I completely understand why you decided to stop taking it after reading something like that. The word 'cancer' immediately raises concerns, but in this case it is important to separate what we know scientifically from what is often interpreted based on information found online. There is currently no scientific evidence demonstrating that using topical finasteride on the scalp causes breast cancer in women. That does not mean we should claim the risk is absolutely zero, because long-term safety studies specifically in women using topical finasteride are still limited. However, there is also currently no scientific basis for telling a patient that using topical finasteride will cause breast cancer. What exactly is finasteride? Finasteride blocks an enzyme called 5-alpha-reductase, which is responsible for converting part of the testosterone into dihydrotestosterone, or DHT. DHT plays an important role in the progressive miniaturisation of the hair follicle that we observe in androgenetic alopecia. By reducing DHT production around the follicle, we aim to slow down that miniaturisation and preserve, for as long as possible, the ability to produce higher-quality hair. Why use it as a spray? Precisely because we seek to achieve a sufficient concentration of the medication in the scalp while reducing, as much as possible, exposure to the rest of the body. Topical finasteride can be partially absorbed and produce some reduction in circulating DHT, which means that 'topical' does not mean the medication remains exclusively on the skin. However, with appropriate formulations, systemic exposure can be considerably lower than with oral treatment. So where does the concern about breast cancer come from? The relationship between finasteride and breast cancer has been discussed for years because the modification of androgen metabolism can produce hormonal changes, and because some cases of breast cancer were reported in men using oral finasteride. However, a case report does not in itself prove that the medication caused those cancers. And, above all, we cannot directly extrapolate those cases observed in men taking oral finasteride to a woman using a topical formulation on the scalp. To date, we do not have evidence demonstrating an increase in breast cancer in women as a result of using topical finasteride. Should I stop the treatment then? I would not discontinue it solely because you read online that 'finasteride causes breast cancer'. What I would do is review your individual situation. I want to know your age, the concentration you are using, the amount applied daily, how long you have been using it, and whether there is any significant personal or family history of breast cancer. If a woman has previously had hormone-dependent breast cancer, is receiving hormonal oncological treatment, or is in a situation of particularly high risk, the decision deserves an individualised assessment and, where appropriate, coordination with her oncologist or gynaecologist. Not because we know that topical finasteride causes a recurrence, but precisely because the available data in these populations are insufficient to act carelessly. There is another much more well-established precaution: pregnancy. This point is truly essential. Finasteride must not be used during pregnancy due to its anti-androgenic action and the potential risk to the development of a male foetus. In a woman of childbearing age, we must carefully assess the possibility of pregnancy and the necessary contraceptive measures before recommending the treatment. Furthermore, with topical formulations we must ensure that other people — especially a pregnant woman — do not accidentally come into contact with the product while it is still wet on the scalp. My recommendation Do not be afraid of a medication simply because you come across an alarming association on the Internet. But do not use a hormonal treatment for years without medical supervision either. Topical finasteride is a tool that can be very valuable in certain types of androgenetic hair loss, and it allows us to try to act on one of the mechanisms responsible for follicular miniaturisation. With the evidence currently available, we cannot state that topical finasteride increases the risk of breast cancer in women. If the treatment was working and you have stopped it solely out of this concern, I would speak with the doctor who prescribed it before discontinuing it permanently. In medicine, this is precisely what we must do: weigh up the benefit, understand the demonstrated risks, acknowledge what data are still lacking, and not turn a theoretical possibility into a certainty that science has not proven.

— Ana
General

I practice endurance sports and I have always been told that I need to consume a lot of carbohydrates and energy gels. Is that really necessary? Can a runner develop prediabetes?

Hello, Javier, This is a matter I find particularly important, because a very widespread idea still persists in the world of sport: "if I do a lot of endurance training, I can — or should — consume large amounts of carbohydrates". And that is not entirely accurate. Carbohydrates are an extraordinarily useful fuel for exercise, especially as intensity increases or when we sustain prolonged effort. Muscle and liver glycogen plays a fundamental role in performance. I am therefore not against carbohydrates. I am against consuming them without regard for the body's actual needs. An energy gel is not an everyday food Sports gels are designed to provide fast-absorbing carbohydrates during prolonged efforts. In a marathon, a multi-hour cycling event, or certain long-duration training sessions, they can make perfect sense. But going out for a 40- or 50-minute run and routinely taking gels, sugary drinks and energy bars before, during and after training is probably unnecessary for most people. There are amateur runners who end up consuming considerable amounts of sugar throughout the entire week simply because they believe they "need it to train". And this is where we can make a mistake. Can a marathon runner have prediabetes? Absolutely. Being an athlete does not confer metabolic immunity. Physical activity generally improves insulin sensitivity and is one of our most powerful tools for preventing type 2 diabetes. However, a person can run many kilometres and, at the same time, follow an inadequate diet, carry excess visceral fat, have a genetic predisposition, suffer from poor sleep, stress, alcohol consumption or other metabolic factors. In my practice I have seen long-distance runners with impaired glucose levels, insulin resistance or prediabetes. That does not mean that running caused the prediabetes. It means we cannot use exercise as a licence to eat whatever we like. The problem is not carbohydrates, but the context A person who trains intensely for two or three hours has completely different carbohydrate needs from someone who goes for a gentle 45-minute run. Sports nutrition must be adapted to: training duration; intensity; weekly volume; body composition; athletic goals; digestive tolerance; metabolic health; and recovery between sessions. In other words, we must also periodise nutrition, not just training. There are days when we need more carbohydrates and others when we need far fewer. What about gels during a marathon? Here the situation changes. During prolonged efforts, carbohydrate intake can improve performance and delay fatigue. In trained athletes completing long events, current nutritional strategies may call for significant amounts of carbohydrates per hour. But these amounts are used during an extraordinarily high energy demand. We should not apply competition nutrition to our everyday diet. Taking 60 or 90 grams of carbohydrates per hour during an endurance event may have a physiological justification. Taking them sitting at home because you are a runner does not. Why do some runners carry abdominal fat despite being lean? We must also debunk another myth. Sometimes we observe endurance athletes who are very lean in their arms and legs but carry some abdominal adiposity. We should not automatically diagnose 'hypercortisolaemia' or speak of Cushing's syndrome simply based on physical appearance. Cushing's syndrome is a specific endocrinological condition and requires a medical and hormonal diagnosis. Intense exercise transiently raises cortisol, and this is completely physiological. Cortisol helps us mobilise energy during physical effort. The problem can arise when we combine, over a prolonged period, excessive training, insufficient recovery, psychological stress, lack of sleep and inadequate energy availability. That environment can impair recovery, disrupt certain hormonal functions and promote loss of muscle mass. However, this is very different from claiming that running causes Cushing's syndrome. Muscle remains essential A person may weigh very little and yet have a body composition that is metabolically suboptimal. That is why I place great emphasis with my athlete patients on not looking solely at the number on the scales. I want to know: How much muscle do you have? How much visceral fat? What are your glucose levels? Your glycated haemoglobin? Your triglycerides? How are you sleeping? How are you recovering? For me, a metabolically healthy runner is not simply someone capable of completing a marathon. They are someone who also preserves good muscle mass, follows a well-balanced diet, rests properly and maintains healthy metabolic parameters. So, does carbohydrate intake need to be reduced? Not necessarily. They need to be used intelligently. Carbohydrates should be tailored to your training, rather than becoming a permanent obligation simply because you participate in endurance sport. For everyday meals, I prefer to prioritise whole, nutritionally complete foods, and to reserve fast-absorbing sports products for those situations where they genuinely offer an advantage. And if you are a regular runner — particularly from the age of 40–50 onwards — I consider it very reasonable to periodically monitor blood glucose, glycated haemoglobin, lipid profile and other metabolic markers according to your personal history. Because we can run a marathon and still have an underlying metabolic abnormality. One thing does not exclude the other. Exercise is medicine, but so is nutrition. And doing a lot of sport does not indefinitely compensate for a misguided nutritional strategy. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Javier
General

Is running truly good for your health, or can it end up being harmful?

Hello, Alejandro, I was asked this question recently and I found it particularly interesting, because the answer is not simply yes or no. Running can be an extraordinary tool for improving our health and longevity. But, as with many things in medicine, the dose, intensity, recovery and context matter just as much as the activity itself. After reviewing the scientific literature, my conclusion is fairly clear: for most people, running in an appropriate way provides far more benefits than risks. Problems tend to arise when we run too much, too fast, or without having prepared the body beforehand. A powerful metabolic stimulus Running considerably increases energy expenditure and can help maintain a healthy weight, reduce visceral fat and improve insulin sensitivity and metabolic control. But its benefits go far beyond burning calories. Running is an important stimulus for our cardiovascular system. With appropriate training it can increase cardiorespiratory capacity and VO₂ max, improve cardiovascular function and promote a more efficient use of oxygen. And this is particularly relevant because good cardiorespiratory capacity is consistently associated with a lower risk of cardiovascular disease and mortality. We also train our brain Many people are familiar with that sense of wellbeing after running that we call runner's high. Exercise produces changes in different neurotransmission and neuromodulation systems related to endorphins, endocannabinoids, dopamine and serotonin. In addition, physical exercise is linked to changes in BDNF (Brain-Derived Neurotrophic Factor), a protein involved in neuronal plasticity, learning and memory. This is why running regularly can help reduce stress, improve mood, support sleep and form part of a preventive strategy against cognitive decline and certain depressive disorders. Exercise as hormesis There is another concept I find especially interesting: hormesis. When we run, we temporarily subject the body to physiological stress: energy demand increases, the mitochondria work harder, oxygen consumption changes and our cardiovascular, muscular and nervous systems must adapt. When that stimulus is appropriate and we subsequently allow sufficient recovery, the body responds by adapting. In a sense, training involves applying a small dose of stress in order to achieve a positive adaptation afterwards. The problem arises when we accumulate stimulus after stimulus and remove recovery. At that point we stop adapting and simply accumulate fatigue. Where do the problems begin? In my view, the problem is often not running itself; it is how we run. Too fast. Too hard. Too many kilometres. And too soon. A sedentary person should not progress to running long distances in just a few weeks simply because they feel cardiovascularly capable of doing so. The heart may adapt before the tendons, bones and certain musculoskeletal structures do. This is why an inappropriate increase in training load can contribute to tendinopathies, patellofemoral pain, plantar fasciitis, periostitis or stress fractures, among other injuries. Not every run has to leave us exhausted There is still a 'no pain, no gain' culture that I consider quite misguided. A good training session is not one in which you finish completely drained every single day. A large part of endurance training can be carried out at low or moderate intensities, reserving truly intense sessions for specific moments in the training plan. Training continuously at relatively high intensities, without sufficient rest and with inadequate energy intake, can increase fatigue, impair recovery and reduce performance. Cortisol rises physiologically during exercise, and that is not a bad thing: it is part of our normal response to effort. The problem is a context of chronic physiological stress, insufficient recovery and low energy availability. For this reason, we should not automatically interpret certain physical changes in runners as a consequence of 'having high cortisol'. Physiology is considerably more complex than that. Running does not replace strength training This is probably one of the messages I am most keen to convey. If you want to age well, you should not limit your physical activity solely to cardiovascular exercise. We need to preserve muscle. Muscle mass plays a role in mobility, glucose metabolism, stability, fall prevention and our future independence. Running provides muscular stimulus, particularly in the lower limbs, but it does not replace a complete strength training programme. As the years pass, this becomes even more important. For this reason, if I were to design a longevity strategy, I would combine cardiovascular exercise + strength training + mobility + adequate recovery. We must also ensure sufficient energy and protein intake through nutrition, especially when training volume is high. What about footwear? Here too we must avoid overly absolute statements. There is a great deal of debate about minimalist and maximalist shoes, drop, cushioning and running technique. We do not have sufficient evidence to state that a highly cushioned shoe is necessarily harmful, nor that running barefoot is better for everyone. What matters is individual biomechanics, progressive adaptation, foot and full kinetic chain strength, training load and using footwear in which the person can run comfortably. Suddenly changing shoe type or running technique can also cause injuries. So, doctor, do you recommend running? Yes. For a person with no medical contraindications, I absolutely recommend cardiovascular activity, and running can be a magnificent way to achieve it. It is accessible, relatively affordable, independent and extraordinarily easy to adapt to each person's level. But I do not recommend turning every outing into a competition against ourselves. Running more kilometres does not automatically mean being healthier. Running faster does not either. My approach would be far simpler: run enough to stimulate the body, recover enough to allow it to adapt and train for strength to preserve muscle and functionality. And listen to your body. If every week you are more tired, sleeping worse, your performance is declining, repetitive injuries are appearing, you are losing strength or you are beginning to train out of obligation rather than enjoyment, your body is probably telling you that the balance between training and recovery needs to be reviewed. The true purpose of exercise should not be to finish exhausted. It should be to build a body that is metabolically healthier, cardiovascularly more efficient, muscularly stronger and more functional for as many years as possible. That, to me, is training for health and for longevity. Kind regards, Doctor Florian A. Vallecillo Cabrera

— Alejandro
salud femenina

I am 23 years old and since I started taking spironolactone my period has not come. I am approximately one month late. Could this be related to the treatment? Should I be worried?

Hello, Lucía, Yes, spironolactone can cause changes to the menstrual cycle, so what you are noticing may well be related to your treatment. Although spironolactone is primarily a diuretic medication, it also has an important anti-androgenic effect. For this reason, we use it quite frequently in young women to treat conditions such as hormonal acne, excess sebum production, or certain cases of hirsutism. Precisely because of this hormonal action, some women may experience changes in their menstrual cycle: periods that come earlier or later than expected, light spotting between periods, irregular cycles, and occasionally a temporary absence of menstruation. This effect may also depend on the dose used and tends to be more common at higher doses. Therefore, if your period has stopped since starting treatment, spironolactone is a possible explanation and does not necessarily mean that there is a serious underlying problem. However, there is something we should always check first. If there is any possibility of pregnancy, please take a test. In a 23-year-old woman with a one-month menstrual delay, regardless of whether she is taking spironolactone, the first step is to rule out pregnancy if there has been any possibility of this. This is especially important because spironolactone should not be used during pregnancy due to its anti-androgenic effects. If the test is negative and your cycles were previously regular, we can monitor how things progress and assess whether the change clearly coincides with the start of treatment or with an increase in dose. Will my period return to normal? In many patients, the menstrual changes associated with spironolactone are reversible and may improve over time, with a dose adjustment, or, if necessary, by modifying the treatment. However, I would not recommend simply waiting indefinitely assuming that everything is due to the medication. If the absence of menstruation continues, recurs over several cycles, or if other symptoms appear, we should also consider other causes of amenorrhoea: thyroid disorders, polycystic ovary syndrome, significant weight changes, excessive physical exercise, stress, elevated prolactin levels, or other hormonal imbalances. Should I stop taking spironolactone? Not necessarily. If the treatment is working well and there are no other side effects, an isolated menstrual delay does not automatically require it to be discontinued. The right approach is to review the dose, the reason you are taking spironolactone, your medical history, and what your cycles were like before you started. Depending on each individual patient, we may maintain the treatment, adjust the dose, or consider other strategies. In some women who also require contraception, certain hormonal contraceptives may help to regulate the cycle; however, this decision must be personalised and they are not recommended simply to correct an irregular period. Therefore, my recommendation would be simple: take a pregnancy test if there is any possibility, and if it comes back negative, discuss it with the doctor who prescribed the spironolactone so that a proper follow-up can be arranged. Do not be alarmed by a single missed period, as menstrual changes are a known side effect of this medication; however, we should not automatically attribute every absence of menstruation to spironolactone without first ruling out other causes. Warm regards, Doctor Florian A. Vallecillo Cabrera

— Lucía, 23
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