Aesthetic medicine treatments

Polynucleotides

Regenerative medicine to improve the quality of the skin

By Clínica Valorian·Medically reviewed by: Dr. Florian André Vallecillo Cabrera
Updated on July 23, 2026· 4 min read
Polynucleotides

Polynucleotides are regenerative medicine treatments that improve the hydration, firmness and elasticity of the skin by stimulating its natural repair mechanisms, with progressive and completely natural results.

What are polynucleotides?

Polynucleotides are injectable regenerative medicine treatments designed to improve the quality of the skin by stimulating its natural repair mechanisms.

Their objective is not to increase the volume of the face or modify its features, but to favour skin regeneration, improve elasticity, increase hydration and achieve firmer, more luminous and healthier skin.

In recent years they have become one of the most innovative tools for the natural rejuvenation of the skin.

How do they act?

Polynucleotides create a favourable biological environment for tissue repair. After their infiltration, they favour the activity of fibroblasts, the natural production of collagen, the synthesis of elastin, the hydration of the dermis and the regeneration of the tissues.

As a consequence, the skin progressively recovers firmness, elasticity and luminosity.

What problems can they treat?

Polynucleotides are indicated to improve skin ageing, thin skin, loss of elasticity, dehydration, photoageing, fine wrinkles, certain selected superficial scars and the overall quality of the skin.

They can also be used as a complement to other aesthetic medicine treatments.

In which areas can they be applied?

Depending on the needs of the patient, they can be used in:

  • Face.
  • Eye contour.
  • Neck.
  • Décolletage.
  • Back of the hands.
  • Scalp, in specific hair medicine protocols.
  • Other selected body areas.

Each indication must be individualised.

Who can benefit?

Candidates may be patients who wish to improve the quality of their skin, present initial or moderate signs of ageing, seek a progressive and natural rejuvenation, want to improve the skin of the eye contour or prefer regenerative treatments over procedures that provide volume.

How is the treatment performed?

After a medical assessment, polynucleotides are administered through micro-injections or, in certain areas, using cannulas.

The procedure usually lasts between 20 and 40 minutes. Most patients can resume their usual activity the same day.

When do the results appear?

The results are progressive. During the first weeks the hydration of the skin improves. Subsequently, firmness, elasticity and luminosity increase as the natural regeneration processes advance.

The result continues to evolve over several weeks.

How long do the results last?

The duration depends on age, the initial state of the skin, the protocol performed, lifestyle habits and the individual response.

An initial treatment with several sessions followed by periodic maintenance sessions is usually recommended.

What benefits do they offer?

Polynucleotides make it possible to improve the quality of the skin, favour skin regeneration, increase hydration, improve elasticity, increase firmness, attenuate small wrinkles and achieve more luminous and uniform skin.

All this while completely respecting the expression and the facial anatomy.

Are there side effects?

Like any injectable treatment, mild and transient side effects can appear: redness, inflammation, small bruises, local sensitivity and slight swelling during the first hours.

Significant complications are infrequent when the procedure is performed by an experienced doctor.

What care should be followed afterwards?

After the treatment it is usually recommended to avoid intense exercise during the first 24 hours, avoid saunas and intense heat for one or two days, avoid direct sun exposure during the first days, not manipulate the treated area and follow the recommendations of the doctor.

Can they be combined with other treatments?

Yes. They are frequently combined with skinboosters, collagen biostimulators, hyaluronic acid, neuromodulators, medical lasers, medical peels and other regenerative medicine procedures.

The combination makes it possible to design completely personalised protocols.

When to consult?

It is advisable to request a medical assessment when the skin has lost quality, you observe dehydration or loss of elasticity, you wish to prevent skin ageing, you seek a regenerative treatment with natural results or you want to improve the delicate skin of the eye contour.

Myths and facts

  • Myth: Polynucleotides increase the volume of the face. Fact: No. Their purpose is to regenerate the skin and improve its quality, not to provide volume.
  • Myth: The results are immediate. Fact: Skin regeneration takes time, so the improvement appears progressively.
  • Myth: They are only useful for older people. Fact: They can also be used preventively to maintain healthy skin and delay the signs of ageing.
  • Myth: They replace all other aesthetic treatments. Fact: They are one more tool within a personalised rejuvenation plan and can be combined with other procedures.
  • Myth: The results look artificial. Fact: Precisely, one of their main objectives is to improve the quality of the skin while completely respecting naturalness.

The essential points to remember

  • Polynucleotides are regenerative treatments that improve the quality of the skin.
  • They favour the natural production of collagen and the repair of the tissues.
  • They do not provide volume or modify the facial features.
  • The results appear progressively and maintain a very natural appearance.
  • They are especially useful to improve the skin of the face, the neck and the eye contour.
  • The individualised medical assessment makes it possible to design the most appropriate protocol for each patient.

Frequently asked questions

Is the treatment painful?

It generally produces mild and well-tolerated discomfort.

Does it need anaesthesia?

In many cases topical anaesthesia is used to increase the comfort of the patient.

How many sessions are necessary?

It depends on the state of the skin and the recommended protocol. Several initial sessions are usually performed.

When will I notice the improvement?

The hydration improves in the first weeks and the regeneration continues progressively over the following months.

Can they be used around the eyes?

Yes. It is one of the areas where they are most frequently used to improve the quality of the skin.

Can they be combined with hyaluronic acid?

Yes. Both treatments are complementary and have different objectives.

Are they suitable for men?

Yes. They improve the quality of the skin without modifying the facial features.

Are the results permanent?

No. Ageing continues naturally, so maintenance sessions are usually recommended.

At what age can they be used?

There is no fixed age. The indication depends on the state of the skin and the objectives of the patient.

Who should perform this treatment?

Always a doctor with specific training in aesthetic medicine and regenerative medicine.

Need personalised guidance?

This guide is for information only and does not replace a medical consultation. For an assessment tailored to your case, you may request a consultation.

Request a consultation

More guides in this category

Platelet-rich plasma (PRP)
Aesthetic medicine treatments

Platelet-rich plasma (PRP)

Platelet-rich plasma (PRP) is a regenerative medicine treatment that uses the growth factors present in the patient's own blood to improve the quality of the skin and favour the natural regeneration of the tissues.

July 23, 2026Read the guide
Exosomes
Aesthetic medicine treatments

Exosomes

Exosomes are vesicles involved in cellular communication that, within regenerative medicine protocols and in accordance with the regulations in force, can contribute to improve the quality of the skin and favour the regeneration of the tissues.

July 23, 2026Read the guide
Microneedling
Aesthetic medicine treatments

Microneedling

Microneedling is a regenerative medical treatment that stimulates collagen production through microneedles to improve texture, scars, pores, fine wrinkles and the overall quality of the skin.

July 23, 2026Read the guide
Skinboosters
Aesthetic medicine treatments

Skinboosters

Skinboosters are injectable treatments that improve the hydration, elasticity and luminosity of the skin without modifying the facial volume, providing a natural and progressive rejuvenation.

July 23, 2026Read the guide
Chemical peels
Aesthetic medicine treatments

Chemical peels

Chemical peels are medical treatments that favour the renewal of the skin and help to improve acne, spots, texture, luminosity and the signs of ageing through personalised protocols.

July 23, 2026Read the guide
Clear + Brilliant® laser
Aesthetic medicine treatments

Clear + Brilliant® laser

The Clear + Brilliant® laser is a non-ablative fractional treatment that improves the luminosity, texture and quality of the skin, stimulating collagen production with a reduced recovery time.

July 23, 2026Read the guide

You might also like

Master Index

Related content

Patient guides

CallWhatsAppBook

We use cookies to improve your experience and for analytics.

+